Only a minor annoyance, but I use my home desk setup for my personal PC and my work laptop, and switch between them with a KVM switch.
Sometimes I lose game sound when switching back, other times not, and it's impossible to get it back when it happens other than relaunching from scratch. In cases where it's lost forever FFXI won't show up on the Volume Mixer at all. In cases where I can still salvage it without relaunching, only sound effects work (foot steps, targeting, spell casting), but zone background music is gone - this is remedied by zoning.
Realize it's a bit esoteric and will vary depending on the actual KVM hardware, but any chance anyone's aware of a simple windows setting that might help fix this? I actually used to play with music/sound effects all the way off, but now that I've started playing with them again I find it annoying when they're gone.